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The formatter Template:Uncommanum removes commas from the input number, regardless of how many commas. However, the result must be a number.
Usage:  {{uncommanum|2,123}}
{{uncommanum|2,300.50|2}}
{{uncommanum|2,400.501|3}}
{{uncommanum|2,1,2,3,,,78}}

Parameter 1 is the number to uncomma, and optional parameter 2 is the rounding level (default: 0).